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. 1988 Feb;78(2):137-9.
doi: 10.1007/BF00278183.

The molecular basis of HbH disease in Taiwan

H W Peng  1 , S H Han, T Y Chow, C H Ho, K N Ching, B N Chiang
Affiliations

The molecular basis of HbH disease in Taiwan

H W Peng et al. Hum Genet. 1988 Feb.

Abstract

We have determined the molecular characteristics of alpha-thalassemia in 12 HbH subjects from Taiwan by restriction endonuclease mapping with alpha- and zeta-specific probes. We have found four types of defects in the alpha-thalassemia-2 genetic determinant: -alpha 3.7 type I; -alpha 4.2; alpha CS alpha; and alpha alpha T. All HbH subjects carried the --SEA genotype in the alpha-thalassemia-1 determinant. At least two different subtypes of --SEA genotype were observed in this study.

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