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. 1988;85(2):227-31.
doi: 10.1159/000234507.

Regulation of IgE-dependent antiparasite functions of rat macrophages and platelets by nedocromil sodium

T Thorel  1 , M Joseph, H Vorng, A Capron
Affiliations

Regulation of IgE-dependent antiparasite functions of rat macrophages and platelets by nedocromil sodium

T Thorel et al. Int Arch Allergy Appl Immunol. 1988.

Abstract

The IgE-dependent stimulation of mononuclear phagocytes and blood platelets can be measured by antiparasite cytotoxicity, oxygen-mediated chemiluminescence and, in macrophages, lysosomal enzyme activity. Using these parameters, the present study demonstrated an inhibition by nedocromil sodium of the IgE-mediated triggering of the nonmast cell inflammatory populations in the rat. These observations suggest that nedocromil sodium may be of value in the modulation of IgE-dependent cell activation inducing the release of inflammatory mediators.

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