Effect of FiO2 in the measurement of VO2 and VCO2 using the E-COXV metabolic monitor

Abstract

Objective: We evaluated the effect of changes in FiO₂ on the bias and accuracy of the determination of oxygen consumption (V˙O₂) and carbon dioxide production (V˙CO₂) using the E-COVX monitor in patients with mechanical ventilation.

Design: Descriptive of concordance.

Setting: Intensive Care Unit.

Patients or participants: Patients with mechanical ventilation.

Interventions: We measured V˙O₂ and V˙CO₂ using the E-COVX monitor. Values recorded were the average in 5min. Two groups of 30 patients. We analyzed: 1) the reproducibility in the measurement of V˙O₂ and V˙CO₂ at FiO₂ 0.4, and 2) the effect of the changes in FiO₂ on the measurement of V˙O₂ and V˙CO₂. Statistical analysis was performed using Bland and Altman test.

Variables of main interest: Bias and accuracy.

Results: 1) FiO₂ 0.4 reproducibility: The bias in the measurement of V˙O₂ and V˙CO₂ was 1.6 and 2.1mL/min, respectively, and accuracy was 9.7 to -8.3% and 7.2 to -5.2%, respectively, and 2) effect of FiO₂ on V˙O₂: The bias of V˙O₂ measured at FiO₂ 0.4 and 0.6 was -4.0mL/min and FiO₂ 0.4 and 0.8 was 5.2mL/min. Accuracy between FiO₂ 0.4 and 0.6 was 11.9 to -14.1%, and between FiO₂ 0.4 and 0.8 was 43.9 to -39.7%.

Conclusions: The E-COVX monitor evaluates V˙O₂ and V˙CO₂ in critical patients with mechanical ventilation with a clinically acceptable accuracy until FiO₂ 0.6.

Keywords: Carbon dioxide; Consumo de oxígeno; Critical illness; Dióxido de carbono; Intercambio pulmonar de gases; Mechanical ventilation; Oxygen consumption; Paciente crítico; Pulmonary gas exchange; Reproducibilidad de resultados; Reproducibility of results; Ventilación mecánica.