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Case Reports
. 2017 May:184:227-229.e1.
doi: 10.1016/j.jpeds.2017.02.008. Epub 2017 Mar 8.

Premature Ovarian Failure in French Canadian Leigh Syndrome

Chiraz Ghaddhab  1 , Charles Morin  2 , Catherine Brunel-Guitton  3 , Grant A Mitchell  3 , Guy Van Vliet  1 , Céline Huot  4
Affiliations
Case Reports

Premature Ovarian Failure in French Canadian Leigh Syndrome

Chiraz Ghaddhab et al. J Pediatr. 2017 May.

Abstract

In all surviving girls with Leigh syndrome, French Canadian variety, a mitochondrial disease, we detected premature ovarian failure, manifested as absent or arrested breast development, lack of menarche, high follicle-stimulating hormone, a prepubertal uterus, and small ovaries. Pubertal onset and progression should be evaluated in girls with mitochondrial diseases.

Keywords: metabolic acidosis; premature ovarian failure.

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Comment in

  • Hypogonadism in mitochondrial disorders.
    Finsterer J, Zarrouk-Mahjoub S. Finsterer J, et al. J Pediatr. 2017 Aug;187:334. doi: 10.1016/j.jpeds.2017.04.063. Epub 2017 May 23. J Pediatr. 2017. PMID: 28549633 No abstract available.
  • Reply.
    Ghaddhab C, Morin C, Brunel-Guitton C, Mitchell GA, Van Vliet G, Huot C. Ghaddhab C, et al. J Pediatr. 2017 Aug;187:334-335. doi: 10.1016/j.jpeds.2017.04.067. Epub 2017 May 24. J Pediatr. 2017. PMID: 28550952 No abstract available.

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