Palaeopathology of the earlobe crease (Frank's sign): New insights from Renaissance art

Francesco M Galassi¹, Claudio Borghi², Roberta Ballestriero³, Michael E Habicht⁴, Maciej Henneberg⁵, Frank J Rühli⁶

Affiliations

¹ Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: francesco.galassi@iem.uzh.ch.
² Medical and Surgical Sciences Department, University of Bologna, Via Massarenti 9, Bologna, Italy.
³ University of the Arts, Central Saint Martins, Granary Building, 1 Granary Square, King's Cross, London N1C 4AA, UK; The Gordon Museum of Pathology, Kings College London, Guy's Campus, St. Thomas' Street, London SE1 9RT, UK.
⁴ Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; School of Humanities and Creative Arts (Department of Archaeology), Flinders University, Adelaide 5001, Australia.
⁵ Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Biological Anthropology and Comparative Anatomy Unit, University of Adelaide, Adelaide 5005, Australia.
⁶ Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

PMID: 28284502
DOI: 10.1016/j.ijcard.2017.02.128

Palaeopathology of the earlobe crease (Frank's sign): New insights from Renaissance art

Francesco M Galassi et al. Int J Cardiol. 2017.

. 2017 Jun 1:236:82-84.

doi: 10.1016/j.ijcard.2017.02.128. Epub 2017 Feb 27.

Authors

Francesco M Galassi¹, Claudio Borghi², Roberta Ballestriero³, Michael E Habicht⁴, Maciej Henneberg⁵, Frank J Rühli⁶

Affiliations

¹ Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: francesco.galassi@iem.uzh.ch.
² Medical and Surgical Sciences Department, University of Bologna, Via Massarenti 9, Bologna, Italy.
³ University of the Arts, Central Saint Martins, Granary Building, 1 Granary Square, King's Cross, London N1C 4AA, UK; The Gordon Museum of Pathology, Kings College London, Guy's Campus, St. Thomas' Street, London SE1 9RT, UK.
⁴ Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; School of Humanities and Creative Arts (Department of Archaeology), Flinders University, Adelaide 5001, Australia.
⁵ Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Biological Anthropology and Comparative Anatomy Unit, University of Adelaide, Adelaide 5005, Australia.
⁶ Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

PMID: 28284502
DOI: 10.1016/j.ijcard.2017.02.128

Erratum in

Corrigendum to "Palaeopathology of the earlobe crease (Frank's sign): New insights from Renaissance art" [International journal of Cardiology 236 (2017) 82-84].
Galassi FM. Galassi FM. Int J Cardiol. 2023 Aug 1;384:117. doi: 10.1016/j.ijcard.2023.03.052. Epub 2023 May 11. Int J Cardiol. 2023. PMID: 37173203 No abstract available.

Abstract

Several studies have associated the earlobe crease sign, discovered by Sanders T. Frank in 1973, with cardiovascular pathology, yet very few studies have focused on the antiquity of this trait, with the most ancient one thought to date back to the Roman Emperor Hadrian (76-138CE). This article presents two more cases from the Italian Renaissance in the works of the artist Andrea Mantegna (1431-1506) and examines them in a multidisciplinary fashion.

Keywords: Cardiovascular pathology; Earlobe crease; Frank's sign; Mantegna; Palaeopathology; Prevention; Renaissance.

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Palaeopathology of the earlobe crease (Frank's sign): New insights from Renaissance art

Affiliations

Palaeopathology of the earlobe crease (Frank's sign): New insights from Renaissance art

Authors

Affiliations

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Abstract

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