A step forward for patients with NRAS-mutant melanoma
- PMID: 28284558
- PMCID: PMC5540131
- DOI: 10.1016/S1470-2045(17)30172-9
A step forward for patients with NRAS-mutant melanoma
Abstract
Steve Gschmeissner/Science Photo Library
Comment on
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Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial.Lancet Oncol. 2017 Apr;18(4):435-445. doi: 10.1016/S1470-2045(17)30180-8. Epub 2017 Mar 9. Lancet Oncol. 2017. PMID: 28284557 Clinical Trial.
References
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- Ascierto PA, Schadendorf D, Berking C, et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. The Lancet Oncology. 2013;14(3):249–56. - PubMed
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- Dougherty MK, Muller J, Ritt DA, et al. Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell. 2005;17(2):215–24. - PubMed
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