A Clinically Distinct and 'Atypical' Subgroup of Head and Neck Cancers Positive for a CpG Island Methylator Phenotype

Affiliations

¹ University of Southern California, USC Norris Comprehensive Cancer Center, Department of Biochemistry and Molecular Medicine, 1450 Biggy St., NRT G511D, Los Angeles, CA 90033, USA. Electronic address: dan.weisenberger@med.usc.edu.

Comment

Daniel J Weisenberger. EBioMedicine. 2017 Mar.

. 2017 Mar:17:22-23.

doi: 10.1016/j.ebiom.2017.03.008. Epub 2017 Mar 6.

¹ University of Southern California, USC Norris Comprehensive Cancer Center, Department of Biochemistry and Molecular Medicine, 1450 Biggy St., NRT G511D, Los Angeles, CA 90033, USA. Electronic address: dan.weisenberger@med.usc.edu.

No abstract available

Comment on

Identification of an atypical etiological head and neck squamous carcinoma subtype featuring the CpG island methylator phenotype.
Brennan K, Koenig JL, Gentles AJ, Sunwoo JB, Gevaert O. Brennan K, et al. EBioMedicine. 2017 Mar;17:223-236. doi: 10.1016/j.ebiom.2017.02.025. Epub 2017 Mar 1. EBioMedicine. 2017. PMID: 28314692 Free PMC article.

1. Brennan K., Koenig J.L., Gentles A.J., Sunwoo J.B., Gevaert O. Identification of an atypical etiological head and neck squamous cell carcinoma subtype featuring the CpG Island Methylator Phenotype. EBioMedicine. 2017;17:223–236. (this issue) - PMC - PubMed
1. The Cancer Genome Atlas Network Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015;517:576–582. - PMC - PubMed
1. Chiappinelli K.B., Strissel P.L., Desrichard A., Li H., Henke C., Akman B. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses. Cell. 2015;162:974–986. - PMC - PubMed
1. Economopoulou P., Perisanidis C., Giotakis E.I., Psyrri A. The emerging role of immunotherapy in head and neck squamous cell carcinoma (HNSCC): anti-tumor immunity and clinical applications. Ann. Transl. Med. 2016;4:173. - PMC - PubMed
1. Liu M., Ohtani H., Zhou W., Orskov A.D., Charlet J., Zhang Y.W. Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine. Proc. Natl. Acad. Sci. U. S. A. 2016;113:10238–10244. - PMC - PubMed