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. 2017:33:92-96.
doi: 10.1016/j.ijscr.2017.02.044. Epub 2017 Feb 27.

Glycogen Rich Clear Cell Carcinoma (GRCC) of the breast may not have a poor prognosis

Muna M Baslaim  1 , Enaam M Junainah  2 , Hadeel H Ahmad  3 , Anmar F Semilan  3 , Ahmed O Al-Ghamdi  3 , Noora O Rahimuddin  3 , Budoor A Salman  4
Affiliations

Glycogen Rich Clear Cell Carcinoma (GRCC) of the breast may not have a poor prognosis

Muna M Baslaim et al. Int J Surg Case Rep. 2017.

Abstract

Introduction: Glycogen Rich Clear Cell Carcinoma (GRCC) is a rare variant of breast carcinomas and believed to be linked with a poor prognosis.

Case summary: We are presenting a 60-year-old Saudi lady with a 2cm GRCC carcinoma associated with clear cell ductal carcinoma in situ (DCIS) and no axillary lymph node involvement. The tumor was Estrogen and Progesterone receptors (ER & PR) positive and HER 2-neu negative. She underwent mastectomy with sentinel lymph node biopsy followed by hormonal therapy. She is alive and free of disease for 35 months.

Conclusion: The prognosis of GRCC may not be different from other types of invasive breast cancer.

Keywords: Case report; Glycogen rich clear cell carcinoma; Rare breast carcinoma sub-types.

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Figures

Fig 1
Fig 1
A. A right mammogram, cranio-caudal view showing an area of asymmetric density. B. A spot magnification compression view shows an elongated mass with irregular margins and faint calcifications.
Fig. 2
Fig. 2
A right breast ultrasound showing a hypodense lobulated horizontally oriented lesion (A) with peripheral vascularity (B).
Fig. 3
Fig. 3
MRI showed an irregular mass with distortion; it has an irregular enhancement at the margins. Multiple benign looking axillary lymph nodes are seen with preserved fatty hilum.
Fig. 4
Fig. 4
A. DCIS of solid type, intermediate grade. Note the clear cytoplasm in the populated cells of the DCIS and the adjacent invasive area of ductal type (H&E × 40). B. Invasive area of ductal type forming cords and nests made of malignant round to polygonal cells. These cells that exhibit clear cytoplasm constitutes more than 90% of the tumor (H&E × 40). C. The granules in the glycogen component of the clear cell are positive for Periodic Acid-Schiff staining (PAS × 40).
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