Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017:2017:1476402.
doi: 10.1155/2017/1476402. Epub 2017 Feb 14.

Assessment of 105 Patients with Angiotensin Converting Enzyme-Inhibitor Induced Angioedema

Eva Rye Rasmussen  1 , Christian von Buchwald  1 , Mia Wadelius  2 , Sumangali Chandra Prasad  3 , Shailajah Kamaleswaran  3 , Kawa Khaled Ajgeiy  3 , Georg Authried  3 , Kristine Appel U Pallesen  3 , Anette Bygum  3
Affiliations

Assessment of 105 Patients with Angiotensin Converting Enzyme-Inhibitor Induced Angioedema

Eva Rye Rasmussen et al. Int J Otolaryngol. 2017.

Erratum in

Abstract

Objective. To asses a cohort of 105 consecutive patients with angiotensin converting enzyme-inhibitor induced angioedema with regard to demographics, risk factors, family history of angioedema, hospitalization, airway management, outcome, and use of diagnostic codes used for the condition. Study Design. Cohort study. Methods. This was a retrospective cohort study of 105 patients with angiotensin converting enzyme-inhibitor induced angioedema in the period 1995-2014. Results. The cohort consisted of 67 females and 38 males (F : M ratio 1.8), with a mean age of 63 [range 26-86] years. Female gender was associated with a significantly higher risk of angiotensin converting enzyme-inhibitor induced angioedema. 6.7% had a positive family history of angioedema. Diabetes seemed to be a protective factor with regard to angioedema. 95% experienced angioedema of the head and neck. 4.7% needed intubation or tracheostomy. 74 admissions took place during the study period with a total of 143 days spent in the hospital. The diagnosis codes most often used for this condition were "DT783 Quincke's oedema" and "DT78.4 Allergy unspecified". Complement C1 inhibitor was normal in all tested patients. Conclusion. Female gender predisposes to angiotensin converting enzyme-inhibitor induced angioedema, whereas diabetes seems to be a protective factor.

PubMed Disclaimer

Conflict of interest statement

Dr. Eva Rye Rasmussen has previously collaborated with Shire®, MSD Norway®, CSL Behring®, and Viropharma® regarding research and teaching within the field of hereditary and pharmacologically induced angioedema. Anette Bygum has received research grant support and/or speaker/consultancy fees from CSL Behring, Viropharma, and Shire/Jerini AG and participated in a clinical trial for Jerini AG and BioCryst. She is an advisor for the HAE Scandinavian Patient Organization. She is a member of the IOS Steering Committee and participates in a clinical study in collaboration with BioCryst. Viropharma is now part of the Shire group of companies. Shire® has previously supported Dr. Eva Rye Rasmussen with a research grant for her studies on other skin manifestations in angioedema patients.

Figures

Figure 1
Figure 1
Age distribution of the cohort.
See this image and copyright information in PMC

References

    1. Tai S., Mascaro M., Goldstein N. A. Angioedema: a review of 367 episodes presenting to three tertiary care hospitals. Annals of Otology, Rhinology and Laryngology. 2010;119(12):836–841. doi: 10.1177/000348941011901208. - DOI - PubMed
    1. Roberts D. S., Mahoney E. J., Hutchinson C. T., Aliphas A., Grundfast K. M. Analysis of recurrent angiotensin converting enzyme inhibitor-induced angioedema. The Laryngoscope. 2008;118(12):2115–2120. doi: 10.1097/mlg.0b013e318182f805. - DOI - PubMed
    1. Holm J. P. Y., Ovesen T. Increasing rate of angiotensin-converting enzyme inhibitor-related upper airway angio-oedema. Danish Medical Journal. 2012;59(6)A4449 - PubMed
    1. Ishoo E., Shah U. K., Grillone G. A., Stram J. R., Fuleihan N. S. Predicting airway risk in angioedema: staging system based on presentation. Otolaryngology—Head and Neck Surgery. 1999;121(3):263–268. doi: 10.1016/s0194-5998(99)70182-8. - DOI - PubMed
    1. Pare G., Kubo M., Byrd J. B., et al. Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenetics and Genomics. 2013;23(9):470–478. doi: 10.1097/FPC.0b013e328363c137. - DOI - PMC - PubMed

LinkOut - more resources