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. 1988 Mar;62(3):1076-9.
doi: 10.1128/JVI.62.3.1076-1079.1988.

Specific interactions between transcription factors and the promoter-regulatory region of the human cytomegalovirus major immediate-early gene

P Ghazal  1 , H Lubon, L Hennighausen
Affiliations

Specific interactions between transcription factors and the promoter-regulatory region of the human cytomegalovirus major immediate-early gene

P Ghazal et al. J Virol. 1988 Mar.

Abstract

Repeat sequence motifs as well as unique sequences between nucleotides -150 and -22 of the human cytomegalovirus immediate-early 1 gene interact in vitro with nuclear proteins. We show that a transcriptional element between nucleotides -91 and -65 stimulated promoter activity in vivo and in vitro by binding specific cellular transcription factors. Finally, a common sequence motif, (T)TGG/AC, present in 15 of the determined binding sites suggests a particular class of nuclear factors associated with the immediate-early 1 gene.

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References

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