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. 2017;5(1):e2.
Epub 2017 Jan 8.

Ketorolac versus Magnesium Sulfate in Migraine Headache Pain Management; a Preliminary Study

Hossein Delavar Kasmaei  1 , Marzieh Amiri  2 , Ahmed Negida  3 , Samaneh Hajimollarabi  4 , Nastaransadat Mahdavi  5
Affiliations

Ketorolac versus Magnesium Sulfate in Migraine Headache Pain Management; a Preliminary Study

Hossein Delavar Kasmaei et al. Emerg (Tehran). 2017.

Abstract

Introduction: Migraine is a common cause of emergency department (ED) visits. To date, there is no recommended drug of choice for pain management of these patients. In the present study, we aimed to evaluate the effectiveness of ketorolac and magnesium sulfate in this regard.

Methods: This is a cross-sectional study performed on all 18 - 60 year-old patients, visiting two different EDs with complaint of moderate to severe migraine headache. Patients were treated with 30 mg ketorolac in one hospital and 1 gram magnesium sulfate in the other. Pain scores were assessed on arrival, 1 and 2 hours after drugs administration and quality of pain management was compared between two groups using SPSS 22.

Results: 70 patients with the mean age of 36.4 ± 11.4 years were enrolled (51.4% male). The two groups were similar regarding baseline characteristics (p > 0.05). The improvement in pain score in magnesium sulfate group was greater than Ketorolac group after both one hour (6 vs 3; p < 0.001) and two hours (7 vs 5; p < 0.001).

Conclusion: It seems that both ketorolac and magnesium sulfate are significantly effective in pain control of patients with migraine headache presenting to the emergency department. Magnesium sulfate was superior to ketorolac both one and two hours after drug administration.

Keywords: Magnesium sulfate; emergency department; ketorolac; migraine disorders; pain management.

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Conflict of interest statement

All authors declare that there is no conflict of interest in this study.

Figures

Figure 1
Figure 1
Box plot comparing minimum, maximum, median and inter-quartile range of pain scores at baseline, 1 hour, and 2 hours after drug administration between ketorolac and magnesium sulfate groups (p < 0.001
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References

    1. Láinez MJ, García-Casado A, Gascón F. Optimal management of severe nausea and vomiting in migraine: improving patient outcomes. Patient related outcome measures. 2013;4:61. - PMC - PubMed
    1. Baratloo A, Negida A, El Ashal G, Behnaz N. Intravenous Caffeine for the Treatment of Acute Migraine: A Pilot Study. Journal of Caffeine Research. :2015.
    1. Friedman BW, Grosberg BM. Diagnosis and management of the primary headache disorders in the emergency department setting. Emergency medicine clinics of North America. 2009;27(1):71–87. - PMC - PubMed
    1. DeMaagd G. The pharmacological management of migraine, part 2: preventative therapy. Pharmacy and Therapeutics. 2008;33(8):480. - PMC - PubMed
    1. Friedman BW, Kapoor A, Friedman MS, Hochberg ML, Rowe BH. The relative efficacy of meperidine for the treatment of acute migraine: a meta-analysis of randomized controlled trials. Annals of emergency medicine. 2008;52(6):705–13. - PMC - PubMed

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