Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1988 Mar;62(3):962-9.
doi: 10.1128/JVI.62.3.962-969.1988.

B-cell lymphoproliferation and lymphomagenesis are associated with clonotypic intracellular terminal regions of the Epstein-Barr virus

N A Brown  1 , C R Liu, Y F Wang, C R Garcia
Affiliations
Comparative Study

B-cell lymphoproliferation and lymphomagenesis are associated with clonotypic intracellular terminal regions of the Epstein-Barr virus

N A Brown et al. J Virol. 1988 Mar.

Abstract

We analyzed 17 B-cell lineages cloned from two patients with infectious mononucleosis and found that different B-cell lineages exhibited notable variation in the length of the fused Epstein-Barr virus (EBV) terminal region on intracellular EBV episomes. EBV termini in different B-cell clones from the same person differed by as many as 15 to 20 reiterations of the ca. 500-base-pair terminal repeat sequence. In contrast, analysis of seven B-cell lineages cloned from a patient with a fatal, oligoclonal lymphoma revealed that three of the cell clones had the same-sized EBV terminal region. These three clones had previously been shown, by immunoglobulin gene analysis, to be metastatic daughter cells descended from a common progenitor. Similarity of the EBV terminal regions in the three daughter clones suggested that EBV infected the progenitor cell before proliferation and metastasis. Individual, EBV-infected cells from a single individual showed sufficient heterogeneity in their EBV termini to allow use of terminal fragment size as a clonal marker in studies addressing the contribution of EBV to the clonal pathogenesis of tumors with which this virus has been associated.

PubMed Disclaimer

References

    1. J Immunol. 1982 Jan;128(1):24-9 - PubMed
    1. Cell. 1986 Dec 26;47(6):883-9 - PubMed
    1. J Infect Dis. 1982 Oct;146(4):506-17 - PubMed
    1. J Bacteriol. 1966 Mar;91(3):1248-56 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Jan;70(1):190-4 - PubMed

Publication types

MeSH terms