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Comment
. 2017 May;13(5):263-264.
doi: 10.1038/nrneph.2017.29. Epub 2017 Mar 13.

Glomerular disease: A suPAR kidney connection found in the bone marrow

Lorenzo Gallon  1 , Susan E Quaggin  1
Affiliations
Comment

Glomerular disease: A suPAR kidney connection found in the bone marrow

Lorenzo Gallon et al. Nat Rev Nephrol. 2017 May.

Abstract

A population of immature myeloid cells in the bone marrow can transfer proteinuric kidney disease from affected to unaffected mice. This new finding highlights a possible central role of bone marrow as the source of the circulating factor(s) that lead to recurrent focal segmental glomerulosclerosis and potentially other kidney diseases.

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Conflict of interest statement

Competing interests statement

L.G. is a consultant for Alexion. S.E.Q. owns stock in and is a director of Mannin Research.

Figures

Figure 1
Figure 1. Hypothetical model for the role of bone-marrow derived factors in the pathogenesis of focal segmental glomerulosclerosis and other proteinuric renal diseases
Initiating factors can stimulate the expansion of Gr-1lo immature myeloid cells, which produce soluble urokinase plasminogen activator receptor (suPAR) and other factors. Increased levels of circulating suPAR are proposed to promote podocyte remodelling, foot-process effacement and proteinuria, via β3-integrin signalling. Modified with permission from Macmillan Publishers Limited © Shankland S. J. & Jefferson, J. A. Nat. Med. 23, 13–14 (2017).
See this image and copyright information in PMC

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References

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