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Review
. 2017 Mar 10;18(3):608.
doi: 10.3390/ijms18030608.

The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling

Jinning Gao  1 , Wenhua Xu  2 , Jianxun Wang  3 , Kun Wang  4 , Peifeng Li  5
Affiliations
Review

The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling

Jinning Gao et al. Int J Mol Sci. .

Abstract

Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. Studies show that ncRNAs are not only involved in cell proliferation, apoptosis, differentiation, metabolism and other physiological processes, but also involved in the pathogenesis of diseases. Cardiac remodeling is the main pathological basis of a variety of cardiovascular diseases. Many studies have shown that the occurrence and development of cardiac remodeling are closely related with the regulation of ncRNAs. Recent research of ncRNAs in heart disease has achieved rapid development. Thus, we summarize here the latest research progress and mainly the molecular mechanism of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), in cardiac remodeling, aiming to look for new targets for heart disease treatment.

Keywords: cardiac remodeling; circular RNA; long non-coding RNA; microRNA; non-coding RNA.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Long non-coding RNA (lncRNA) and circular RNA (circRNA) classification based on genomic location and context.
Figure 2
Figure 2
Summary of the ncRNAs and their molecular mechanisms in cardiac remodeling.
See this image and copyright information in PMC

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