Stirring the Pot: Can Dietary Modification Alleviate the Burden of CKD?

Abstract

Diet is one of the largest modifiable risk factors for chronic kidney disease (CKD)-related death and disability. CKD is largely a progressive disease; however, it is increasingly appreciated that hallmarks of chronic kidney disease such as albuminuria can regress over time. The factors driving albuminuria resolution remain elusive. Since albuminuria is a strong risk factor for GFR loss, modifiable lifestyle factors that lead to an improvement in albuminuria would likely reduce the burden of CKD in high-risk individuals, such as patients with diabetes. Dietary therapy such as protein and sodium restriction has historically been used in the management of CKD. Evidence is emerging to indicate that other nutrients may influence kidney health, either through metabolic or haemodynamic pathways or via the modification of gut homeostasis. This review focuses on the role of diet in the pathogenesis and progression of CKD and discusses the latest findings related to the mechanisms of diet-induced kidney disease. It is possible that optimizing diet quality or restricting dietary intake could be harnessed as an adjunct therapy for CKD prevention or progression in susceptible individuals, thereby reducing the burden of CKD.

Keywords: advanced glycation end products; albuminuria; cardiovascular disease; chronic kidney disease; diabetes; diet; inflammation.

Figure 1

Mechanisms of dietary factors impact on chronic kidney disease. n-3 PUFAs = Omega 3 Polyunsaturated Fatty Acids. CRP = C-Reactive Protein. MCP-1 = Monocyte Chemoattractant Protein-1.