Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jul 4;8(5):571-576.
doi: 10.1080/21505594.2017.1305532. Epub 2017 Mar 13.

Aging metabolism: intervention strategies

Esteban Martinez  1
Affiliations
Review

Aging metabolism: intervention strategies

Esteban Martinez. Virulence. .

Abstract

Human beings are subjected to aging and age-associated diseases. Life expectancy has improved impressively in the last century due to social and economic development, but despite increasing improvement is still more limited than average in those ones with chronic diseases such as treated HIV infection. There has been a substantial research on the underlying factors responsible for aging both in the general and the HIV-infected populations. Several specific targets for potential intervention have been identified but studies so far have been limited to small experiments in cultured cells or living beings other than humans such as mice or flies. Time has come for designing and developing human studies with those candidate therapies showing most promising benefits and least potential toxicities to treat age-related diseases.

Keywords: HIV infection; aging; intervention; metabolism; strategies.

PubMed Disclaimer

References

    1. Hung WW, Ross JS, Boockvar KS, Siu AL. Recent trends in chronic disease, impairment and disability among older adults in the United States. BMC Geriatr 2011; 11:47; PMID:21851629; https://doi.org/10.1186/1471-2318-11-47 - DOI - PMC - PubMed
    1. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013; 153:1194-217; PMID:23746838; https://doi.org/10.1016/j.cell.2013.05.039 - DOI - PMC - PubMed
    1. Legarth RA, Ahlström MG, Kronborg G, Larsen CS, Pedersen C, Pedersen G, Mohey R, Gerstoft J, Obel N. Long-term mortality in HIV-infected individuals 50 years or older: a nationwide, population-based cohort study. J Acquir Immune Defic Syndr 2016; 71:213-8; PMID:26334734; https://doi.org/10.1097/QAI.0000000000000825 - DOI - PubMed
    1. Marcus J, Chao C, Leyden WA, Xu L, Quesenberry CP Jr, Klein DB, Towner WJ, Horberg MA, Silverberg MJ. Narrowing the gap in life expectancy for HIV+ compared with HIV-Infected and HIV-Uninfected Individuals With Access to Care. J Acquir Immune Defic Syndr 2016; 73(1): 39-46; https://doi.org/10.1097/QAI.0000000000001014 - DOI - PMC - PubMed
    1. Wada NI, Jacobson LP, Margolick JB, Breen EC, Macatangay B, Penugonda S, Martínez-Maza O, Bream JH. The effect of HAART-induced HIV suppression on circulating markers of inflammation and immune activation. AIDS 2015; 29:463-71; PMID:25630041; https://doi.org/10.1097/QAD.0000000000000545 - DOI - PMC - PubMed

LinkOut - more resources