The Gut Microbiome and Its Role in Cardiovascular Diseases

Affiliations

¹ From Department of Cellular and Molecular Medicine, Lerner Research Institute (W.H.W.T., S.L.H.); Department of Cardiovascular Medicine, Heart and Vascular Institute (W.H.W.T., S.L.H.); Center for Microbiome and Human Health (W.H.W.T., S.L.H.), and Center for Clinical Genomics (W.H.W.T.), Cleveland Clinic, OH. tangw@ccf.org.
² From Department of Cellular and Molecular Medicine, Lerner Research Institute (W.H.W.T., S.L.H.); Department of Cardiovascular Medicine, Heart and Vascular Institute (W.H.W.T., S.L.H.); Center for Microbiome and Human Health (W.H.W.T., S.L.H.), and Center for Clinical Genomics (W.H.W.T.), Cleveland Clinic, OH.

W H Wilson Tang et al. Circulation. 2017.

. 2017 Mar 14;135(11):1008-1010.

doi: 10.1161/CIRCULATIONAHA.116.024251.

¹ From Department of Cellular and Molecular Medicine, Lerner Research Institute (W.H.W.T., S.L.H.); Department of Cardiovascular Medicine, Heart and Vascular Institute (W.H.W.T., S.L.H.); Center for Microbiome and Human Health (W.H.W.T., S.L.H.), and Center for Clinical Genomics (W.H.W.T.), Cleveland Clinic, OH. tangw@ccf.org.
² From Department of Cellular and Molecular Medicine, Lerner Research Institute (W.H.W.T., S.L.H.); Department of Cardiovascular Medicine, Heart and Vascular Institute (W.H.W.T., S.L.H.); Center for Microbiome and Human Health (W.H.W.T., S.L.H.), and Center for Clinical Genomics (W.H.W.T.), Cleveland Clinic, OH.

No abstract available

Keywords: coronary artery disease; diet; gut microbes; heart failure; metabolism; nutrition.

Figures

1. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472:57–63. - PMC - PubMed
1. Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013;19:576–585. - PMC - PubMed
1. Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368:1575–1584. - PMC - PubMed
1. Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WH, DiDonato JA, Brown JM, Lusis AJ, Hazen SL. Gut microbial metabolite tmao enhances platelet hyperreactivity and thrombosis risk. Cell. 2016;165:111–124. - PMC - PubMed
1. Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL. Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis. Cell. 2015;163:1585–1595. - PMC - PubMed