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Comment
. 2017 Apr 3;149(4):405.
doi: 10.1085/jgp.201711783. Epub 2017 Mar 13.

Sodium ion unlocks understanding of channel blockade

Caitlin Sedwick
Comment

Sodium ion unlocks understanding of channel blockade

Caitlin Sedwick. J Gen Physiol. .

Abstract

New simulations explain how several types of drugs block sodium channels.

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Figures

None
Simulations performed by co-authors Denis Tikhonov (left) and Boris Zhorov (right) demonstrate how sodium channel blockers that bind near the Nav1.4 selectivity filter (circled region 1) achieve current blockade in the presence and absence of a sodium ion (yellow). Photos courtesy of the authors.
See this image and copyright information in PMC

Comment on

References

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