Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?

Deborah Naon^{1

2}, Marta Zaninello^{1

3

4}, Marta Giacomello^{1

3}, Tatiana Varanita^{1

3}, Francesca Grespi^{1

3}, Sowmya Lakshminaranayan^{1

4}, Annalisa Serafini^{1

3}, Martina Semenzato^{1

3}, Stephanie Herkenne^{1

3}, Maria Isabel Hernández-Alvarez⁵, Antonio Zorzano⁵, Diego De Stefani², Gerald W Dorn 2nd⁶, Luca Scorrano^{7

3}

Affiliations

¹ Department of Biology, University of Padua, 35121 Padua, Italy.
² Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy.
³ Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padua, Italy.
⁴ Fondazione S. Lucia Istituto di Recovero e Cura a Carattere Scientifico, 00161 Rome, Italy.
⁵ Institute for Research in Biomedicine, 08028 Barcelona, Spain.
⁶ Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO 63110.
⁷ Department of Biology, University of Padua, 35121 Padua, Italy; luca.scorrano@unipd.it.

PMID: 28289205
PMCID: PMC5373396
DOI: 10.1073/pnas.1618610114

Comment

Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?

Deborah Naon et al. Proc Natl Acad Sci U S A. 2017.

. 2017 Mar 21;114(12):E2268-E2269.

doi: 10.1073/pnas.1618610114. Epub 2017 Mar 13.

Authors

Affiliations

¹ Department of Biology, University of Padua, 35121 Padua, Italy.
² Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy.
³ Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padua, Italy.
⁴ Fondazione S. Lucia Istituto di Recovero e Cura a Carattere Scientifico, 00161 Rome, Italy.
⁵ Institute for Research in Biomedicine, 08028 Barcelona, Spain.
⁶ Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO 63110.
⁷ Department of Biology, University of Padua, 35121 Padua, Italy; luca.scorrano@unipd.it.

PMID: 28289205
PMCID: PMC5373396
DOI: 10.1073/pnas.1618610114

No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Comment on

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether.
Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato M, Herkenne S, Hernández-Alvarez MI, Zorzano A, De Stefani D, Dorn GW 2nd, Scorrano L. Naon D, et al. Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11249-11254. doi: 10.1073/pnas.1606786113. Epub 2016 Sep 19. Proc Natl Acad Sci U S A. 2016. PMID: 27647893 Free PMC article.
On the role of Mitofusin 2 in endoplasmic reticulum-mitochondria tethering.
Filadi R, Greotti E, Turacchio G, Luini A, Pozzan T, Pizzo P. Filadi R, et al. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2266-E2267. doi: 10.1073/pnas.1616040114. Epub 2017 Mar 13. Proc Natl Acad Sci U S A. 2017. PMID: 28289206 Free PMC article. No abstract available.

References

1. Filadi R, et al. On the role of Mitofusin 2 in endoplasmic reticulum–mitochondria tethering. Proc Natl Acad Sci USA. 2017;114:E2266–E2267. - PMC - PubMed
1. Naon D, et al. Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether. Proc Natl Acad Sci USA. 2016;113(40):11249–11254. - PMC - PubMed
1. Filadi R, et al. Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling. Proc Natl Acad Sci USA. 2015;112(17):E2174–E2181. - PMC - PubMed
1. de Brito OM, Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature. 2008;456(7222):605–610. - PubMed
1. Alford SC, Ding Y, Simmen T, Campbell RE. Dimerization-dependent green and yellow fluorescent proteins. ACS Synth Biol. 2012;1(12):569–575. - PMC - PubMed

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Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?

Affiliations

Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?

Authors

Affiliations

Conflict of interest statement

Comment on

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

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