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. 2017 Sep;27(9):3716-3724.
doi: 10.1007/s00330-017-4768-1. Epub 2017 Mar 13.

The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment

Janne M Papma  1 , Marion Smits  2 , Marius de Groot  2   3 , Francesco U Mattace Raso  4 , Aad van der Lugt  2 , Henri A Vrooman  2   3 , Wiro J Niessen  2   3   5 , Peter J Koudstaal  6 , John C van Swieten  6 , Frederik M van der Veen  7 , Niels D Prins  8
Affiliations

The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment

Janne M Papma et al. Eur Radiol. 2017 Sep.

Abstract

Objectives: Diminished function of the posterior cingulate cortex (PCC) is a typical finding in early Alzheimer's disease (AD). It is hypothesized that in early stage AD, PCC functioning relates to or reflects hippocampal dysfunction or atrophy. The aim of this study was to examine the relationship between hippocampus function, volume and structural connectivity, and PCC activation during an episodic memory task-related fMRI study in mild cognitive impairment (MCI).

Method: MCI patients (n = 27) underwent episodic memory task-related fMRI, 3D-T1w MRI, 2D T2-FLAIR MRI and diffusion tensor imaging. Stepwise linear regression analysis was performed to examine the relationship between PCC activation and hippocampal activation, hippocampal volume and diffusion measures within the cingulum along the hippocampus.

Results: We found a significant relationship between PCC and hippocampus activation during successful episodic memory encoding and correct recognition in MCI patients. We found no relationship between the PCC and structural hippocampal predictors.

Conclusions: Our results indicate a relationship between PCC and hippocampus activation during episodic memory engagement in MCI. This may suggest that during episodic memory, functional network deterioration is the most important predictor of PCC functioning in MCI.

Key points: • PCC functioning during episodic memory relates to hippocampal functioning in MCI. • PCC functioning during episodic memory does not relate to hippocampal structure in MCI. • Functional network changes are an important predictor of PCC functioning in MCI.

Keywords: Diffusion tensor imaging; Episodic memory task-related functional MRI; Hippocampus; Mild cognitive impairment; Posterior cingulate cortex.

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Figures

Fig. 1
Fig. 1
Activation and deactivation patterns in successful encoding versus baseline and correct recognition versus baseline, lenient threshold without correction for multiple comparisons. Coronal view in posterior cingulate cortex (PCC) region
Fig. 2
Fig. 2
Activation of the hippocampus extending into the parahippocampal gyrus in mild cognitive impairement (MCI) patients during recognition, lenient threshold without multiple comparisons
See this image and copyright information in PMC

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