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. 2017 Mar 14;14(3):e1002256.
doi: 10.1371/journal.pmed.1002256. eCollection 2017 Mar.

Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery

David A Bennett  1
Affiliations

Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery

David A Bennett. PLoS Med. .

Abstract

In a Perspective, David Bennett makes a case for neural reserve to be considered as a therapeutic endpoint in clinical trials for dementia.

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Conflict of interest statement

I have read the journal's policy and have the following conflicts: DAB serves on the Adjudication Committee for AD4833/TOMM40_301, Takeda Pharmaceuticals USA, Inc. and the Neuro Safety Data Monitoring Committee for ABBV-8E12, M15-566, AbbVie, Inc. DAB serves on the Scientific Advisory Board for Vigorous Minds, Inc.

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