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Comment
. 2017 Mar 13;40(5):427-428.
doi: 10.1016/j.devcel.2017.02.024.

RNA Methylation Clears the Way

Cassandra Kontur  1 , Antonio Giraldez  2
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Free article
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RNA Methylation Clears the Way

Cassandra Kontur et al. Dev Cell. .
Free article

Abstract

During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but interrelated pathways. A recent study in Nature by Zhao et al. (2017) finds that YTHDF2, a reader of N6- methylation, facilitates maternal mRNA decay, introducing an additional facet of control over transcript fate and developmental reprogramming.

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