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. 1987;93(3):314-9.
doi: 10.1007/BF00187249.

Expression of morphine-conditioned hyperactivity is attenuated by naloxone and pimozide

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Expression of morphine-conditioned hyperactivity is attenuated by naloxone and pimozide

J L Neisewander et al. Psychopharmacology (Berl). 1987.

Abstract

The present experiments assessed whether morphine-conditioned hyperactivity could be attenuated by either the opiate antagonist naloxone or the dopamine antagonist pimozide. Both of these antagonists were shown to block the unconditioned hyperactivity induced by 2 mg/kg morphine (Experiment 1). Rats were then conditioned by pairing this dose of morphine repeatedly with a distinctive environment (Experiment 2). Following several drug-environment pairings, rats displayed a hyperactive conditioned response (CR) when exposed to the environment in the absence of the drug. CR expression was counteracted by 1 mg/kg naloxone and was attenuated by pimozide (0.25, 0.33, and 0.4 mg/kg) in a dose-related manner. These findings suggest that the unconditioned and conditioned hyperactive responses produced by morphine may involve similar neuropharmacologic substrates.

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References

    1. Pharmacol Biochem Behav. 1981 Oct;15(4):559-62 - PubMed
    1. Nature. 1979 Apr 5;278(5704):560-2 - PubMed
    1. J Pharmacol Exp Ther. 1981 May;217(2):451-60 - PubMed
    1. Life Sci. 1982 Nov 15-22;31(20-21):2347-50 - PubMed
    1. Life Sci. 1981 Feb 16;28(7):755-60 - PubMed

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