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. 2017 Apr:211:194-198.
doi: 10.1016/j.ejogrb.2017.02.020. Epub 2017 Feb 20.

Influence of high risk HPV genotype on colposcopic performance: A large prospective study demonstrates improved detection of disease with ZedScan I, particularly in non-HPV 16 patients

Madeleine C Macdonald  1 , Brian H Brown  2 , Rachel E Lyon  3 , T Jamie Healey  4 , Julia E Palmer  3 , John A Tidy  3
Affiliations

Influence of high risk HPV genotype on colposcopic performance: A large prospective study demonstrates improved detection of disease with ZedScan I, particularly in non-HPV 16 patients

Madeleine C Macdonald et al. Eur J Obstet Gynecol Reprod Biol. 2017 Apr.

Abstract

Objective: To assess the influence of high-risk Human Papilloma Virus (hrHPV) genotyping on the detection of high-grade disease (CIN2+) using colposcopic impression both with and without electrical impedance spectroscopy (ZedScan I) as an adjunct.

Study design: A prospective cohort of women with a known hrHPV genotype referred to a single colposcopy service.

Results: 839 women underwent colposcopy and ZedScan I examination. 613 women were referred with abnormal cytology; 411 (67%) with low-grade dyskaryosis (67%) and 202 (33%) with high-grade dyskaryosis. 187 were referred with persistent hrHPV but negative cytology. 35 were attended for follow up and 4 for a clinical indication. 159 (19%) women were positive for HPV16 only; 54 (6%) with HPV18 only, 443 (53%) women were positive for hrHPV other types (HPV O). 183 (22%) were positive for multiple hrHPV genotypes. CIN2+ was present in 170 (84.2%) of high-grade and 69 (16.7%) of low-grade cytology referrals. Colposcopy was better at detecting HPV16 associated CIN2+ than that associated with HPV18 or HPV O (86.9% vs 79.7%, p=0.0191). ZedScan I increased the detection of CIN2+ from 85.6% to 96% irrespective of hrHPV genotype status (p<0.0001).

Conclusion: The use of an electrical impedance spectroscopic device (ZedScan I) increases detection of CIN2+ irrespective of hrHPV genotype.

Keywords: Electrical impedance spectroscopy; High-grade CIN; ZedScan; hrHPV genotype.

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