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. 2017 Jan;42(1):57-65.

The Effect of Four Different Gonadotropin Protocols on Oocyte and Embryo Quality and Pregnancy Outcomes in IVF/ICSI Cycles; A Randomized Controlled Trial

Mohammad Ebrahim Parsanezhad  1 , Bahia Namavar Jahromi  2 , Solmaz Rezaee  3 , Leila Kooshesh  4 , Sanaz Alaee  5
Affiliations

The Effect of Four Different Gonadotropin Protocols on Oocyte and Embryo Quality and Pregnancy Outcomes in IVF/ICSI Cycles; A Randomized Controlled Trial

Mohammad Ebrahim Parsanezhad et al. Iran J Med Sci. 2017 Jan.

Abstract

Background: Despite the large number of papers published on the efficiency of different exogenous gonadotropins, no confirmed protocol exists. Therefore, the aim of the present study was to compare the efficacy of 4 exogenous gonadotropins in IVF/ICSI cycles.

Methods: This study, performed from January 2014 to May 2014, recruited 160 women referred to Ghadir Mother and Child Hospital and Dena Hospital, Shiraz, Iran. The patients underwent standard downregulation and were randomly divided into 4 groups of A, B, C, and D and were administered hMG, hFSH, rFSH, and combined sequential hFSH/rFSH, respectively. Then, the duration of stimulation, number of oocytes and embryos as well as their quality, implantation rate, biochemical and clinical pregnancy rate, and live birth rate in each group were evaluated.

Results: Group D patients required significantly fewer ampoules of FSH than did the women in groups A, B, and C (P=0.004). The duration of stimulation was significantly longer in group C than in groups A and D (P=0.030). The serum estradiol level was significantly higher in group D than in groups B and C (P=0.005). A significantly higher number of large-sized follicles was observed in group D than in group B (P=0.036).

Conclusion: Our data revealed no statistically significant differences in the mean oocyte number, embryo quality, clinical pregnancy rate, or live birth rate between the hMG, hFSH, rFSH, and sequential hFSH/rFSH protocols. However, several differences in the duration of stimulation, serum estradiol levels, and number of large-sized follicles were detected between the groups. Trial Registration Number: IRCT201408116541N7.

Keywords: Gonadotropins; Oocytes; Pregnancy.

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Figures

Figure 1
Figure 1
Study flow chart of the evaluation of the efficacy of different ovarian stimulation protocols, consisting of hFSH, rFSH, hMG, and sequential use of hFSH and rFSH, on oocyte and embryo quality and IVF treatment outcome in patients undergoing IVF or ICSI.
Figure 2
Figure 2
CONSORT flow diagram shows the sampling procedure.
See this image and copyright information in PMC

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