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Review
. 2017 Feb 28:10:53.
doi: 10.3389/fnmol.2017.00053. eCollection 2017.

An Insight into the Increasing Role of LncRNAs in the Pathogenesis of Gliomas

Yuanliang Yan  1 , Zhijie Xu  2 , Zhi Li  3 , Lunquan Sun  3 , Zhicheng Gong  1
Affiliations
Review

An Insight into the Increasing Role of LncRNAs in the Pathogenesis of Gliomas

Yuanliang Yan et al. Front Mol Neurosci. .

Abstract

Long non-coding RNAs (LncRNAs) are essential epigenetic regulators with critical roles in tumor initiation and malignant progression. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of gliomas are not fully understood. With the development of deep sequencing analyses, an extensive amount of functional non-coding RNAs has been discovered in glioma tissues and cell lines. Additionally, the contributions of several lncRNAs, such as Hox transcript antisense intergenic RNA, H19 and Colorectal neoplasia differentially expressed, previously reported to be involved in other pathogenesis and processes to the oncogenesis of glioblastoma are currently addressed. Thus, lncRNAs detected in tumor tissues could serve as candidate diagnostic biomarkers and therapeutic targets for gliomas. To understand the potential function of lncRNAs in gliomas, in this review, we briefly describe the profile of lncRNAs in human glioma research and therapy. Then, we discuss the individual lncRNA that has been under intensive investigation in glioma research, and the focus is its mechanism and clinical implication.

Keywords: diagnostic biomarkers; glioma; lncRNAs; therapeutic targets; therapy.

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Figures

FIGURE 1
FIGURE 1
Classification of lncRNAs according to their genomic location. (1) Transcription start site-associated RNAs may be transcribed from enhancers or promoters. (2) Long intronic ncRNAs may be transcribed from introns of other genes. (3) Natural antisense transcripts contain divergent antisense, nested antisense or terminal antisense. (4) Stand-alone transcription units. (5) Some transcribed pseudogenes.
FIGURE 2
FIGURE 2
Schematic diagram of the two archetypes of lncRNA mechanisms in gliomas. (A) LncRNAs in gliomas can serve as molecular decoys, which take proteins or RNAs away from a specific location. (B) LncRNAs in gliomas can serve as molecular signaling mediators, which modulate the expression of a certain set of genes.
FIGURE 3
FIGURE 3
Roles of lncRNA HOTAIR in glioma malignancy. See text for detailed discussion.
See this image and copyright information in PMC

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