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. 2017 Aug 2;34(3):278-279.
doi: 10.4274/tjh.2017.0031. Epub 2017 Mar 15.

Screening of Intron 1 Inversion of the Factor VIII Gene in 130 Patients with Severe Hemophilia A from a Pakistani Cohort

Azhar Sattar  1 , Shabbir Hussain, Muhammad Ikram Ullah, Saqib Mahmood, Shahida Mohsin
Affiliations

Screening of Intron 1 Inversion of the Factor VIII Gene in 130 Patients with Severe Hemophilia A from a Pakistani Cohort

Azhar Sattar et al. Turk J Haematol. .
No abstract available

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Conflict of interest statement

Conflict of Interest: The authors declare no conflicts of interest, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included.

Figures

Figure 1
Figure 1. Molecular analysis of intron 1 inversion of the factor VIII gene in hemophilia A patients. A) The top panel shows normal results and the lower panel shows the patients with inversion. Diagram of normal DNA (top) and inversion (bottom) showing the location and orientation of relevant sequences as well as polymerase chain reaction primers and reactions (thin bars). B) Amplification of Int1h-1 using 9cR, 9F, and Int1h-2F primers (lanes 1, 2, and 3) and Int1h-2 using Int1h-2F, Int1h-2R, and 9F primers (lanes 4, 5, and 6). Control and inversion are males while the carrier is female.
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