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. 1988 Feb;162(2):483-6.
doi: 10.1016/0042-6822(88)90491-6.

Gene transfer into hematopoietic progenitor cells mediated by an adeno-associated virus vector

D LaFace  1 , P Hermonat, E Wakeland, A Peck
Affiliations

Gene transfer into hematopoietic progenitor cells mediated by an adeno-associated virus vector

D LaFace et al. Virology. 1988 Feb.

Abstract

We describe here the transduction of murine hematopoietic progenitor cells with the dominant selectable neomycin drug-resistance (Neo) gene using a recombinant adeno-associated virus (AAV) vector. Successful transformation of progenitor cells to drug resistance was determined to be approximately 1.5% by colony formation in the presence of geneticin sulfate (G-418). The value of AAV as an alternative to the retrovirus vector systems is discussed.

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