[Comparative Evaluation of -blockers and If-Channel Inhibitor in Patients With Chronic Heart Failure and Preserved Left Ventricular Ejection Fraction]

Abstract

Treatment of patients with chronic heart failure (CHF) and preserved left ventricular (LV) ejection fraction remains largely empirical, as none of the methods of therapy improves the prognosis of patients. In a prospective randomized study on 126 patients with CHF and LV ejection fraction more or equal 50% we compared effectiveness of long-term treatment with bisoprolol (n=62) and ivabradine (n=64). Assessment of clinical status, exercise tolerance (ET), quality of life, blood level of N-terminal brain natriuretic peptide precursor, and parameters of echocardiography was performed at baseline and after 12 months of therapy. Unlike bisoprolol ivabradine, significantly improved exercise tolerance, quality of life, and reduced level of N-terminal brain natriuretic peptide precursor. Improvement of echocardiographic indices of active relaxation and compliance of the left ventricle was also observed. Key words: heart failure with preserved ejection fraction; ivabradine; bisoprolol; left ventricle diastolic dysfunction.