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Editorial
. 2017 May 15;123(10):1695-1698.
doi: 10.1002/cncr.30659. Epub 2017 Mar 13.

Genetic alterations in TRAF3 and CYLD that regulate nuclear factor κB and interferon signaling define head and neck cancer subsets harboring human papillomavirus

Tony Chen  1 , Jialing Zhang  1 , Zhong Chen  1 , Carter Van Waes  1
Affiliations
Editorial

Genetic alterations in TRAF3 and CYLD that regulate nuclear factor κB and interferon signaling define head and neck cancer subsets harboring human papillomavirus

Tony Chen et al. Cancer. .

Abstract

Intriguingly, recent genomic studies of HNSCC by The Cancer Genome Atlas (TCGA) as well as other groups identified deletions or mutations in TNF-receptor associated factor (TRAF3) and Cylindromatosis (CYLD; Turban Tumor Syndrome) that were previously implicated in NF-κB and anti-viral Interferon responses. Hajek et al find genomic alterations in TRAF3/CYLD define distinct subsets of HPV+ HNSCC with associated activation of transcription factor NF-κB, episomal HPV infection of tumors, and improved survival of patients.

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Conflict of interest statement

Conflict of Interest: The authors disclose no conflicts of interest.

Comment on

References

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