Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2017 Mar;96(11):e6375.
doi: 10.1097/MD.0000000000006375.

Efficacy of fresh packed red blood transfusion in organophosphate poisoning

Hang-Xing Bao  1 , Pei-Jian Tong, Cai-Xia Li, Jing Du, Bing-Yu Chen, Zhi-Hui Huang, Ying Wang
Affiliations
Randomized Controlled Trial

Efficacy of fresh packed red blood transfusion in organophosphate poisoning

Hang-Xing Bao et al. Medicine (Baltimore). 2017 Mar.

Abstract

The mortality rate caused by organophosphate (OP) poisoning is still high, even the standard treatment such as atropine and oxime improves a lot. To search for alternative therapies, this study was aimed to investigate the effects of packed red blood cell (RBC) transfusion in acute OP poisoning, and compare the therapeutic effects of RBCs at different storage times.Patients diagnosed with OP poisoning were included in this prospective study. Fresh RBCs (packed RBCs stored less than 10 days) and longer-storage RBCs (stored more than 10 days but less than 35 days) were randomly transfused or not into OP poisoning patients. Cholinesterase (ChE) levels in blood, atropine usage and durations, pralidoxime durations were measured.We found that both fresh and longer-storage RBCs (200-400 mL) significantly increased blood ChE levels 6 hours after transfusion, shortened the duration for ChE recovery and length of hospital stay, and reduced the usage of atropine and pralidoxime. In addition, fresh RBCs demonstrated stronger therapeutic effects than longer-storage RBCs.Packed RBCs might be an alternative approach in patients with OP poisoning, especially during early stages.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Fresh RBC transfusion significantly improved ChE levels of the patients. Blood ChE levels before and after RBC transfusion (fresh or long-storage RBCs respectively) 6 hours were shown. P < 0.01, ANOVA with pair-wise comparisons, compared between before and after RBC transfusion groups.
See this image and copyright information in PMC

References

    1. Catano HC, Carranza E, Huamani C, et al. Plasma cholinesterase levels and health symptoms in peruvian farm workers exposed to organophosphate pesticides. Arch Environ Contam Toxicol 2008;55:153–9. - PubMed
    1. Eddleston M. Patterns and problems of deliberate self-poisoning in the developing world. QJM 2000;93:715–31. - PubMed
    1. Li Y, Tse ML, Gawarammana I, et al. Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning. Clin Toxicol (Phila) 2009;47:179–92. - PubMed
    1. Rickett DL, Glenn JF, Beers ET. Central respiratory effects versus neuromuscular actions of nerve agents. Neurotoxicology 1986;7:225–36. - PubMed
    1. Eddleston M, Buckley NA, Eyer P, et al. Management of acute organophosphorus pesticide poisoning. Lancet 2008;371:597–607. - PMC - PubMed

Publication types