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. 2017 Mar;34(2):211-213.
doi: 10.1111/pde.13089.

Immunohistochemical Staining of Pediatric Solitary Angiokeratomas

Brea Prindaville  1 , Hillary Lawrence  2 , Vivekanand Singh  3 , Amy J Nopper  1 , Kimberly A Horii  1
Affiliations

Immunohistochemical Staining of Pediatric Solitary Angiokeratomas

Brea Prindaville et al. Pediatr Dermatol. 2017 Mar.

Abstract

The precise etiology and subtype of vessels constituting angiokeratomas is poorly understood. We sought to characterize the vessels by studying prospero-related homeobox gene-1 and D2-40 expression in 22 pediatric solitary angiokeratomas. Routine histologic examination demonstrated a mix of lymph-containing vessels and erythrocyte-filled small vessels. Our results suggest that angiokeratomas may in part be comprised of vessels with lymphatic differentiation.

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