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. 1988;98(1-2):107-15.
doi: 10.1007/BF01321011.

Effect of cloned human interferon-alpha 2a on bovine parainfluenza-3 virus. Brief report

P Panigrahi  1 , S B Mohanty, R K Maheshwari, R M Friedman
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Effect of cloned human interferon-alpha 2a on bovine parainfluenza-3 virus. Brief report

P Panigrahi et al. Arch Virol. 1988.

Abstract

Pretreatment of bovine turbinate (BTu) cells with cloned human interferon (IFN)-alpha 2a reduced the yield of infectious bovine parainfluenza-3 virus (PI-3 V). Intracellular synthesis of HN glycoprotein was reduced on postinfection day 1 (PID 1), but it recovered to normal levels subsequently. However, reduction of this protein persisted in the released virus through PID 2. Thin section electron microscopy demonstrated a drastically reduced release of mature virions and an accumulation of viral nucleocapsids inside the cytoplasm on PID 2. These results suggest that cloned human IFN-alpha 2a affects the glycoprotein synthesis, and morphogenesis of bovine PI-3 V, and thus inhibits the release of viral particles from treated cells.

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References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Virus Res. 1984 Jan;1(1):81-7 - PubMed
    1. Cell. 1979 Jun;17(2):255-64 - PubMed
    1. Zentralbl Bakteriol Orig A. 1973 Jun;224(1):61-4 - PubMed
    1. Nature. 1974 Oct 11;251(5475):543-5 - PubMed

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