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Review
. 2017 Mar 15;8(2):240-252.
doi: 10.3945/an.116.013151. Print 2017 Mar.

Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet

Zeinab Mokhtari  1 , Deanna L Gibson  2 , Azita Hekmatdoost  3   4
Affiliations
Review

Nonalcoholic Fatty Liver Disease, the Gut Microbiome, and Diet

Zeinab Mokhtari et al. Adv Nutr. .

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in the world, yet the pathogenesis of the disease is not well elucidated. Due to the close anatomic and functional association between the intestinal lumen and the liver through the portal system, it is speculated that the gut microbiome may play a pivotal role in the pathogenesis of NAFLD. Furthermore, diet, which can modulate the gut microbiome and several metabolic pathways involved in NAFLD development, shows a potential tripartite relation between the gut, diet, and the liver. In this review, we summarize the current evidence that supports the association between NAFLD, the gut microbiome, and the role of diet.

Keywords: NAFLD; NASH; diet; gut microbiota; nonalcoholic fatty liver disease; probiotics.

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Conflict of interest statement

Author disclosures: Z Mokhtari, DL Gibson, and A Hekmatdoost, no conflicts of interest.

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References

    1. Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011;34:274–85. - PubMed
    1. Tiniakos DG, Vos MB, Brunt EM. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol 2010;5:145–71. - PubMed
    1. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346:1221–31. - PubMed
    1. Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos Nutrition and Liver Study. Hepatology 2005;42:44–52. - PubMed
    1. Fan JG, Saibara T, Chitturi S, Kim BI, Sung JJ, Chutaputti A. What are the risk factors and settings for non-alcoholic fatty liver disease in Asia-Pacific? J Gastroenterol Hepatol 2007;22:794–800. - PubMed

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