Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Dec 15;248(3):973-6.
doi: 10.1042/bj2480973.

Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase

O I Aruoma  1 , B Halliwell
Affiliations

Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase

O I Aruoma et al. Biochem J. .

Abstract

The neutrophil enzyme myeloperoxidase generates hypochlorous acid (HOCl) at sites of inflammation. Glutathione peroxidase is very quickly inactivated by low concentration of HOCl. Inactivation of catalase is also rapid, but requires higher HOCl concentrations and the haem appears to be degraded. Inactivation of bovine CuZn superoxide dismutase is slower. Hence superoxide dismutase should not be easily inactivated by HOCl at sites of inflammation, which may contribute to its effectiveness as an anti-inflammatory agent and in minimizing reperfusion injury.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Biochem Biophys Res Commun. 1968 Apr 19;31(2):145-50 - PubMed
    1. Arch Biochem Biophys. 1985 Aug 1;240(2):500-8 - PubMed
    1. Science. 1974 Aug 9;185(4150):529-31 - PubMed
    1. J Clin Invest. 1979 Oct;64(4):913-20 - PubMed
    1. J Clin Invest. 1980 Nov;66(5):908-17 - PubMed

Publication types

MeSH terms