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. 2017 Jan-Mar;11(1):28-33.
doi: 10.4103/0259-1162.194573.

Quality of Labor Epidural Analgesia and Maternal Outcome With Levobupivacaine and Ropivacaine: A Double-Blinded Randomized Trial

T Senthil Kumar  1 , P Rani  1 , V R Hemanth Kumar  1 , Sunita Samal  2 , S Parthasarathy  1 , M Ravishankar  1
Affiliations

Quality of Labor Epidural Analgesia and Maternal Outcome With Levobupivacaine and Ropivacaine: A Double-Blinded Randomized Trial

T Senthil Kumar et al. Anesth Essays Res. 2017 Jan-Mar.

Abstract

Background: Quality of labor analgesia plays a vital role in the maternal outcome. Very few literature are available analyzing the quality of epidural labor analgesia.

Aim: The aim of this study was to compare the effectiveness of 0.1% levobupivacaine and 0.1% ropivacaine with fentanyl as an adjuvant for epidural labor analgesia in terms of onset, duration, quality of analgesia, and degree of motor blockade.

Methodology: Sixty nulliparous parturients, with singleton uncomplicated pregnancy, were recruited by continuous sampling. Parturients were randomized to receive either levobupivacaine 0.1% or ropivacaine 0.1% with 2 μg/ml fentanyl as an intermittent epidural bolus. The epidural analgesia was initiated with 12 ml of study drug solution in the active stage of labor (cervix 3 cm dilated). Demand bolus was given whenever the visual analog scale (VAS) score >3. Onset, duration, and quality of analgesia and degree of motor blockade were analyzed. Maternal outcome was evaluated in terms of mode of delivery, duration of labor, and assisted vaginal delivery.

Statistical analysis: All the data were recorded in Microsoft Office Excel. Statistical analysis was carried out using SPSS version 19.0 (IBM SPSS, USA) software with Regression Modules installed. Descriptive analyses were reported as mean and standard deviation of continuous variables.

Results: The mean onset of analgesia was shorter in ropivacaine (21.43 ± 2 min) than in levobupivacaine group (23.57 ± 1.71 min) (P = 0.000). Duration of analgesia was shorter in ropivacaine (60 ± 14 min) than levobupivacaine (68 ± 11 min) (P = 0.027). Levobupivacaine produced a better quality of analgesia in terms of not perceiving pain and uterine contraction during labor analgesia but was associated with 37% incidence of instrumental delivery. Duration of labor and rate of cesarean section were comparable between the groups.

Conclusion: Quality of analgesia in labor epidural was superior to levobupivacaine but was associated with higher incidence of instrumental vaginal delivery.

Keywords: Instrumental delivery; labor analgesia; levobupivacaine; quality of analgesia; ropivacaine.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Consort diagram.
Figure 2
Figure 2
Quality of analgesia in levobupivacaine and ropivacaine group.
Figure 3
Figure 3
Percentage of mode of delivery in both levobupivacaine and ropivacaine groups.
Figure 4
Figure 4
Percentage of instrumental vaginal delivery in levobupivacaine and ropivacaine groups.
Figure 5
Figure 5
Percentage of fetal Apgar score at 1 and 5 min in levobupivacaine and ropivacaine groups.
Figure 6
Figure 6
Percentage of maternal satisfaction with levobupivacaine and ropivacaine.
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