Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jan-Mar;11(1):78-83.
doi: 10.4103/0259-1162.200244.

A Comparative Evaluation of Ramosetron with Ondansetron for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Urological Procedures

Samiullah Mujoo  1 , Zulfiqar Ali  2 , Majid Jehangir  2 , Asif Iqbal  1 , Nargis Qayoom  3 , Abdul Qayoom Lone  2
Affiliations

A Comparative Evaluation of Ramosetron with Ondansetron for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Urological Procedures

Samiullah Mujoo et al. Anesth Essays Res. 2017 Jan-Mar.

Abstract

Background: Postoperative nausea and vomiting (PONV) is a common problem causing distress to patients in the postoperative period. Younger age, gynecological surgeries, laparoscopic surgeries, female gender, volatile anesthetics, increased duration of anesthesia, and postoperative opioid use are associated with increased incidence of PONV.

Aim: The present study was conducted to study the efficacy of ramosetron and its comparison with ondansetron in the prevention of PONV in patients undergoing pyelolithotomy, pyeloplasty, and upper ureterolithotomy.

Methods: One hundred patients with physical status American Society of Anesthesiologists I and II, aged 20-60 years were enrolled in the study. Patients were randomly distributed to receive either injection ramosetron 0.3 mg intravenously (IV) or injection ondansetron 6 mg IV just before extubation.

Results: There was no significant difference between the groups in age, gender, weight, duration of anesthesia, and duration of surgery. In the patients, who received ramosetron, it was observed that incidence of the episodes of nausea and vomiting increased with time after surgery. Each patient had an episode of nausea and an episode of vomiting during the 6-12 h interval. Similarly, two patients had episodes of nausea and two patients had episodes of vomiting at 18-24 h. This necessitated the increased need for rescue antiemetics with a total of four patients needing rescue antiemetics at 18-24 h. In patients receiving ondansetron, the episodes of nausea were more in number when compared with the ramosetron group. Twelve patients complained of nausea and thirteen patients had episodes of vomiting with the needfor rescue antiemetic in 14 patients. Both genders had a comparable incidence of nausea and vomiting.

Conclusion: A single dose of IV ramosetron (0.3 mg) is more effective when compared with a single dose IV ondansetron (6 mg) in the prevention of PONV. We observed that the benefit was more in the later stages of the postoperative period (12-24 h).

Keywords: Ondansetron; postoperative nausea and vomiting; ramosetron.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Postoperative nausea at different time intervals in Group A (ramosetron group).
Figure 2
Figure 2
Postoperative nausea at different time intervals in Group B (ondansetron group).
Figure 3
Figure 3
Postoperative vomiting at different time intervals in Group A (ramosetron group).
Figure 4
Figure 4
Postoperative vomiting at different time intervals in Group B (ondansetron group).
Figure 5
Figure 5
Postoperative nausea and vomiting score at different time intervals in ramosetron group.
Figure 6
Figure 6
Postoperative nausea and vomiting score at different time intervals in ondansetron group.
See this image and copyright information in PMC

References

    1. Apfel CC, Läärä E, Koivuranta M, Greim CA, Roewer N. A simplified risk score for predicting postoperative nausea and vomiting: Conclusions from cross-validations between two centers. Anesthesiology. 1999;91:693–700. - PubMed
    1. Koivuranta M, Läärä E, Snåre L, Alahuhta S. A survey of postoperative nausea and vomiting. Anaesthesia. 1997;52:443–9. - PubMed
    1. Sinclair DR, Chung F, Mezei G. Can postoperative nausea and vomiting be predicted? Anesthesiology. 1999;91:109–18. - PubMed
    1. Gan TJ. Risk factors for postoperative nausea and vomiting. Anesth Analg. 2006;102:1884–98. - PubMed
    1. Evers AS, Maze M. Antiemetics. Anesthetic Pharmacology, Physiologic Principles and Clinical Practice, A Companion to Miller's Anesthesia. First ed. Ch. 45. Philadelphia: Churchill Livingstone; 2004. p. 777.