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Review
. 2017:2017:9591319.
doi: 10.1155/2017/9591319. Epub 2017 Feb 19.

Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta-Analysis

Yunkai Dai  1 , Yunzhan Zhang  1 , Danyan Li  1 , Jintong Ye  1 , Weijing Chen  1 , Ling Hu  1
Affiliations
Review

Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta-Analysis

Yunkai Dai et al. Evid Based Complement Alternat Med. 2017.

Abstract

Modified Banxia Xiexin decoction (MBXD) is a classical Chinese herbal formula in treating gastroesophageal reflux disease (GERD) for long time, but the efficacy of it is still controversial. This study is to evaluate the efficacy and safety of MBXD for the treatment of GERD in adults. The search strategy was carried out for publications in seven electronic databases. RevMan software version 5.3 and the Cochrane Collaboration's risk of bias tool were performed for this review. Twelve RCTs were included for the analysis. The results of overall clinical efficacy and efficacy under gastroscope demonstrated that MBXD was superior to conventional western medicine. Meanwhile, the results of subgroup analysis showed clinical heterogeneity between the two groups. However, there was no statistically significant difference in acid regurgitation between the two groups. But in the improvement of heartburn and sternalgia, the results showed statistically significant differences for the comparison between two groups. In addition, the adverse reactions of the experiment groups were not different from those of the control groups. This systematic review indicates that MBXD may have potential effects on the treatment of patients with GERD. But because the evidence of methodological quality and sample sizes is weak, further standardized researches are required.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flowchart of the process for literature retrieval.
Figure 2
Figure 2
Risk of bias summary and graph.
Figure 3
Figure 3
Forest plot of overall clinical efficacy (fixed effect model).
Figure 4
Figure 4
Funnel plot of overall clinical efficacy.
Figure 5
Figure 5
Forest plot of subgroup analysis (fixed effect model).
Figure 6
Figure 6
Funnel plot of subgroup analysis.
Figure 7
Figure 7
Forest plot of efficacy under gastroscope (fixed effect model).
Figure 8
Figure 8
Funnel plot of efficacy under gastroscope.
Figure 9
Figure 9
Forest plot of acid regurgitation (random effect model).
Figure 10
Figure 10
Forest plot of heartburn (random effect model).
Figure 11
Figure 11
Forest plot of sternalgia (random effect model).
Figure 12
Figure 12
Forest plot of recurrence rate (random effect model).
See this image and copyright information in PMC

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