Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Oct-Dec;12(4 Suppl):10-13.
doi: 10.14797/mdcj-12-4s1-10.

The Intersection of Pulmonary Hypertension and Solid Organ Transplantation

Adaani E Frost  1
Affiliations
Review

The Intersection of Pulmonary Hypertension and Solid Organ Transplantation

Adaani E Frost. Methodist Debakey Cardiovasc J. 2016 Oct-Dec.

Abstract

Pulmonary hypertension (PH) is a complication and marker of disease severity in many parenchymal lung diseases. It also is a frequent complication of portal hypertension and negatively impacts survival with liver transplant. Pulmonary hypertension is frequently diagnosed in patients with end-stage renal disease who are undergoing dialysis, and it has recently been demonstrated to adversely affect posttransplant outcome in this patient population even though the mechanism of PH is substantially different from that associated with liver disease. The presence of PH in patients with heart failure is frequent, and the necessity for PH therapy prior to heart transplant has evolved in the last decade. We review the frequency of and risk factors for PH in recipients of and candidates for lung, liver, heart, and renal transplants as well as the impact of this diagnosis on posttransplant outcomes.

Keywords: COPD; end-stage renal disease; parenchymal lung disease; pulmonary hypertension.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Survival of 133 patients with idiopathic pulmonary fibrosis with and without interceding pulmonary hypertension. Reprinted from Gläser et al. Pulmonary hypertension in patients with idiopathic pulmonary fibrosis – the predictive value of exercise capacity and gas exchange efficiency. PLoS ONE. 2013 Jun 20;8(6):e65643.
See this image and copyright information in PMC

References

    1. Hoeper MM, Bogaard HJ, Condliffe R, . et al. Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol. 2013. December 24; 62( 25 Suppl): D42– 50. - PubMed
    1. Gomberg-Maitland M, Glassner-Kolmin C, Watson S, . et al. Survival in pulmonary arterial hypertension patients awaiting lung transplantation. J Heart Lung Transplant. 2013. Dec. 32( 12): 1179– 86. - PubMed
    1. Benza RL, Miller DP, Frost A, Barst RJ, Krichman AM, McGoon MD.. Analysis of the lung allocation score estimation of risk of death in patients with pulmonary arterial hypertension using data from the REVEAL Registry. Transplantation. 2010. August 15; 90( 3): 298– 305. - PubMed
    1. American Lung Association [Internet]. Chicago: American Lung Association; c2016. Lung Health & Diseases: How serious is COPD; 2013 [cited 2016 Jul 19]. Available from: http://www.lung.org/lung-health-and-diseases/lung-disease-lookup/copd/le...
    1. Yusen RD, Edwards LB, Kucheryavaya AY, . et al.; International Society for Heart and Lung Transplantation The registry of the International Society for Heart and Lung Transplantation: thirty-first adult lung and heart-lung transplant report–2014; focus theme: retransplantation. J Heart Lung Transplant. 2014. October; 33( 10): 1009– 24. - PubMed

MeSH terms