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Review
. 2017 Feb 20:6:F1000 Faculty Rev-167.
doi: 10.12688/f1000research.10557.1. eCollection 2017.

Recent advances in understanding the cellular roles of GSK-3

Kevin W Cormier  1 , James R Woodgett  1
Affiliations
Review

Recent advances in understanding the cellular roles of GSK-3

Kevin W Cormier et al. F1000Res. .

Abstract

Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed protein kinase that sits at the nexus of multiple signaling pathways. Its deep integration into cellular control circuits is consummate to its implication in diseases ranging from mood disorders to diabetes to neurodegenerative diseases and cancers. The selectivity and insulation of such a promiscuous kinase from unwanted crosstalk between pathways, while orchestrating a multifaceted response to cellular stimuli, offer key insights into more general mechanisms of cell regulation. Here, we review recent advances that have contributed to the understanding of GSK-3 and its role in driving appreciation of intracellular signal coordination.

Keywords: GSK-3; GSK-3 biology; GSK-3 isoform; GSK-3 post-translational modification; glycogen synthase kinase-3.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

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