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. 2017 Feb 22:6:14.
doi: 10.4103/2277-9175.200789. eCollection 2017.

Expression of Estrogen Receptor Alpha in Malignant Melanoma

Parvin Rajabi  1 , Marzieh Bagheri  1 , Mohsen Hani  1
Affiliations

Expression of Estrogen Receptor Alpha in Malignant Melanoma

Parvin Rajabi et al. Adv Biomed Res. .

Abstract

Background: Features of malignant melanoma (MM) vary in the different geographic regions of the world. This may be attributable to environmental, ethnic, and genetic factors. The aim of this study was to determine the expression of estrogen receptor alpha (ER-α) in MM in Isfahan, Iran.

Materials and methods: This study was planned as a descriptive, analytical, cross-sectional investigation. During this study, paraffin-embedded tissue blocks of patients with a histopathologic diagnosis of MM was studied for ER-α using immunohistochemistry (IHC).

Results: In this study, 38 patients (female/male; 20/18) with a definite diagnosis of malignant cutaneous melanoma and mean age of 52.4 ± 11.2 years were investigated. Using envision IHC staining, there were not any cases with ER-α expression.

Conclusion: In confirmation to the most previous studies, expression of ER-α was negative in MM. It is recommended to investigate the expression of estrogen receptor beta and other markers in MM.

Keywords: Estrogen receptor alpha; immunohistochemistry; melanoma.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
The absence of immunohistochemical staining of estrogen receptor alpha in malignant melanoma
See this image and copyright information in PMC

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