Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr:118:112-117.
doi: 10.1016/j.fitote.2017.03.004. Epub 2017 Mar 11.

Five new koumine-type alkaloids from the roots of Gelsemium elegans

Wei Zhang  1 , Sheng-Yuan Zhang  2 , Gui-Yang Wang  3 , Ni-Ping Li  3 , Min-Feng Chen  3 , Ji-Hong Gu  3 , Dong-Mei Zhang  4 , Lei Wang  5 , Wen-Cai Ye  6
Affiliations

Five new koumine-type alkaloids from the roots of Gelsemium elegans

Wei Zhang et al. Fitoterapia. 2017 Apr.

Abstract

Five new koumine-type alkaloids (1-5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy and electronic circular dichroism spectral analyses. The inhibitory effects of compounds 1-11 on the viability of three tumor cell lines (A-649, HepG2, and HuH7) were evaluated by the MTT assay.

Keywords: Cytotoxic activity; Gelsemium elegans; Koumine-type alkaloids.

PubMed Disclaimer

LinkOut - more resources