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. 1987 Nov 24;144(1):105-7.
doi: 10.1016/0014-2999(87)90016-1.

Postnatal handling reduces novelty-induced fear and increases [3H]flunitrazepam binding in rat brain

S R Bodnoff  1 , B Suranyi-Cadotte, R Quirion, M J Meaney
Affiliations

Postnatal handling reduces novelty-induced fear and increases [3H]flunitrazepam binding in rat brain

S R Bodnoff et al. Eur J Pharmacol. .

Abstract

Postnatal handling of rat pups alters their response to novelty. We have now shown that, as adults, rats handled for the first three weeks of life showed a suppression of feeding in a novel environment that was less, and a [3H]flunitrazepam binding in whole brain that was greater than in non-handled animals. These data suggest that variations in benzodiazepam binding capacity could be related to individual differences in the fear response to novelty.

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