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Comment
. 2017 Apr 1;131(7):621-623.
doi: 10.1042/CS20160956.

HIF1α in aortic aneurysms and beyond

Tomoki Hashimoto  1 , Victor Rizzo  2
Affiliations
Comment

HIF1α in aortic aneurysms and beyond

Tomoki Hashimoto et al. Clin Sci (Lond). .

Abstract

Abdominal aortic aneurysm (AAA) is a permanent expansion of the vessel wall with a high prevalence in those 65 years of age and older. Aneurysms are prone to dissection and rupture that carry a mortality rate of over 85%. Currently, surgical repair is the only option to treat this disease. The need to intervene prior to these events has set off a flurry of basic studies in an effort to understand the cellular and molecular mechanisms that govern AAA formation, progression and rupture. In the present study, the role of myeloid cells in contributing to AAA development has been confirmed. More specifically, the transcription factor, hypoxia-inducible factor-1α (HIF1α), was demonstrated to be a necessary component for regulating the expression of extracellular matrix modifying enzymes and their endogenous inhibitors in these cells. This new discovery may lead to therapeutic targets to prohibit the degradation and weakening of the vessel wall with the hope of limiting AAA formation and/or growth.

Keywords: aneurysm; hypoxia-inducible factors; translational science.

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Conflict of interest statement

Competing interests

The authors declare that there are no competing interests associated with the manuscript.

Comment on

References

    1. Daugherty A, Cassis L. Chronic angiotensin II infusion promotes atherogenesis in low density lipoprotein receptor −/− mice. Ann N Y Acad Sci 1999;892:108–118. - PubMed
    1. Daugherty A, Manning MW, Cassis LA. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 2000;105(11):1605–1612. PMCID: PMC300846. - PMC - PubMed
    1. Cassis LA, Gupte M, Thayer S, Zhang X, Charnigo R, Howatt DA, Rateri DL, Daugherty A. ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol 2009;296(5):H1660–1665. PMCID: PMC2685354. - PMC - PubMed
    1. Obama T, Tsuji T, Kobayashi T, Fukuda Y, Takayanagi T, Taro Y, Kawai T, Forrester SJ, Elliott KJ, Choi E, Daugherty A, Rizzo V, Eguchi S. Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model. Clinical science 2015;128(9):559–565. - PubMed
    1. Takayanagi T, Crawford KJ, Kobayashi T, Obama T, Tsuji T, Elliott KJ, Hashimoto T, Rizzo V, Eguchi S. Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase. Clinical science 2014;126(11):785–794. PMCID: PMC4019733. - PMC - PubMed

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