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Review
. 2017 May 3;42(1):49-60.
doi: 10.1247/csf.17003. Epub 2017 Mar 7.

PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides

Junya Hasegawa  1 , Bethany S Strunk  1 , Lois S Weisman  1
Affiliations
Review

PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides

Junya Hasegawa et al. Cell Struct Funct. .

Abstract

In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions. Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) are extremely low relative to some other PIs, emerging evidence demonstrates that both lipids are crucial for the endocytic pathway, intracellular signaling, and adaptation to stress. Mutations that causes defects in the biosynthesis of PI5P and PI(3,5)P2 are linked to human diseases including neurodegenerative disorders. Here, we review recent findings on cellular roles of PI5P and PI(3,5)P2, as well as the pathophysiological importance of these lipids.Key words: Phosphoinositides, Membrane trafficking, Endocytosis, Vacuoles/Lysosomes, Fab1/PIKfyve.

Keywords: Endocytosis; Fab1/PIKfyve; Membrane trafficking; Phosphoinositides; Vacuoles/Lysosomes.

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Figures

Fig. 1
Fig. 1
Interconversion pathways of seven phosphoinositide lipids. The action of lipid kinases is indicated as red arrows, and the action of phosphatases is indicated as blue arrows. The action of phospholipase C (PLC) is indicated by a green arrow.
Fig. 2
Fig. 2
Phosphoinositides are localized at distinct sites within the intracellular membrane system. The reported localization of each phosphoinositide is shown as the color indicated in the key.
See this image and copyright information in PMC

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