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Meta-Analysis
. 2017 Mar 17:23:58-86.
doi: 10.12659/msmbr.902557.

Platelets Cellular and Functional Characteristics in Patients with Atrial Fibrillation: A Comprehensive Meta-Analysis and Systematic Review

Alexander Weymann  1 , Sadeq Ali-Hasan-Al-Saegh  2 , Anton Sabashnikov  3   4 , Aron-Frederik Popov  5 , Seyed Jalil Mirhosseini  2 , Luis Nombela-Franco  6 , Luca Testa  7 , Mohammadreza Lotfaliani  2 , Mohamed Zeriouh  3   4 , Tong Liu  8 , Hamidreza Dehghan  9 , Senol Yavuz  10 , Michel Pompeu Barros de Oliveira Sá  11   12   13 , William L Baker  14 , Jae-Sik Jang  15 , Mengqi Gong  8 , Umberto Benedetto  16 , Pascal M Dohmen  1 , Fabrizio D'Ascenzo  17 , Abhishek J Deshmukh  18 , Giuseppe Biondi-Zoccai  19   20 , Hugh Calkins  21 , Gregg W Stone  22 , Integrated Meta-Analysis Of Cardiac Surgery And Cardiology-Group Imcsc-Group  23
Affiliations
Meta-Analysis

Platelets Cellular and Functional Characteristics in Patients with Atrial Fibrillation: A Comprehensive Meta-Analysis and Systematic Review

Alexander Weymann et al. Med Sci Monit Basic Res. .

Abstract

BACKGROUND This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of platelet cellular and functional characteristics including platelet count (PC), MPV, platelet distribution width (PDW), platelet factor 4, beta thromboglobulin (BTG), and p-selectin with the occurrence of atrial fibrillation (AF) and consequent stroke. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating platelet characteristics in patients with paroxysmal, persistent and permanent atrial fibrillations. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. RESULTS Literature search of all major databases retrieved 1,676 studies. After screening, a total of 73 studies were identified. Pooled analysis showed significant differences in PC (weighted mean difference (WMD)=-26.93 and p<0.001), MPV (WMD=0.61 and p<0.001), PDW (WMD=-0.22 and p=0.002), BTG (WMD=24.69 and p<0.001), PF4 (WMD=4.59 and p<0.001), and p-selectin (WMD=4.90 and p<0.001). CONCLUSIONS Platelets play a critical and precipitating role in the occurrence of AF. Whereas distribution width of platelets as well as factors of platelet activity was significantly greater in AF patients compared to SR patients, platelet count was significantly lower in AF patients.

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Conflict of interest statement

Declaration of interest

The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Forest plot of weighted mean difference (WMD) for association between platelet count and occurrence of AF.
Figure 2
Figure 2
Forest plot of weighted mean difference (WMD) for association between level of mean platelet volume and occurrence of AF.
Figure 3
Figure 3
Forest plot of weighted mean difference (WMD) for association between level of beta thromboglobulin and occurrence of AF.
Figure 4
Figure 4
Forest plot of weighted mean difference (WMD) for association between level of platelet factor 4 and occurrence of AF.
Figure 5
Figure 5
Forest plot of weighted mean difference (WMD) for association between level of P-selectin and occurrence of AF.
See this image and copyright information in PMC

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