Review

. 2017 May;17(5):302-317.

doi: 10.1038/nrc.2017.6. Epub 2017 Mar 17.

Pre-metastatic niches: organ-specific homes for metastases

Héctor Peinado^{1

2}, Haiying Zhang¹, Irina R Matei¹, Bruno Costa-Silva^{1

3}, Ayuko Hoshino¹, Goncalo Rodrigues^{1

4}, Bethan Psaila⁵, Rosandra N Kaplan⁶, Jacqueline F Bromberg⁷, Yibin Kang^{8

9}, Mina J Bissell¹⁰, Thomas R Cox¹¹, Amato J Giaccia¹², Janine T Erler¹³, Sachie Hiratsuka¹⁴, Cyrus M Ghajar¹⁵, David Lyden^{1

16}

Affiliations

¹ Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA.
² Microenvironment and Metastasis Group, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain.
³ Systems Oncology Group, Champalimaud Research, Champalimaud Centre for the Unknown, Avenida Brasília, Doca de Pedrouços, 1400-038 Lisbon, Portugal.
⁴ Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, 4099-003 Porto, Portugal.
⁵ Centre for Haematology, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0HS, UK.
⁶ Center for Cancer Research, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10-Hatfield CRC, Room 1-3940, Bethesda, Maryland 20892, USA.
⁷ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
⁸ Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
⁹ Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA.
¹⁰ Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
¹¹ The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia.
¹² Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA.
¹³ Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Copenhagen 2200, Denmark.
¹⁴ Department of Pharmacology, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-cho, Tokyo 162-8666, Japan.
¹⁵ Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
¹⁶ Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

PMID: 28303905
DOI: 10.1038/nrc.2017.6

Free article

Review

Pre-metastatic niches: organ-specific homes for metastases

Héctor Peinado et al. Nat Rev Cancer. 2017 May.

Free article

. 2017 May;17(5):302-317.

doi: 10.1038/nrc.2017.6. Epub 2017 Mar 17.

Authors

Affiliations

¹ Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA.
² Microenvironment and Metastasis Group, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain.
³ Systems Oncology Group, Champalimaud Research, Champalimaud Centre for the Unknown, Avenida Brasília, Doca de Pedrouços, 1400-038 Lisbon, Portugal.
⁴ Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, 4099-003 Porto, Portugal.
⁵ Centre for Haematology, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0HS, UK.
⁶ Center for Cancer Research, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10-Hatfield CRC, Room 1-3940, Bethesda, Maryland 20892, USA.
⁷ Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
⁸ Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
⁹ Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA.
¹⁰ Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
¹¹ The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2010, Australia.
¹² Department of Radiation Oncology, Stanford University, Stanford, California 94305, USA.
¹³ Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), Copenhagen 2200, Denmark.
¹⁴ Department of Pharmacology, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-cho, Tokyo 162-8666, Japan.
¹⁵ Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
¹⁶ Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

PMID: 28303905
DOI: 10.1038/nrc.2017.6

Abstract

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

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Pre-metastatic niches: organ-specific homes for metastases

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