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Meta-Analysis
. 2017 Mar 17:7:44789.
doi: 10.1038/srep44789.

Effects of exercise-based cardiac rehabilitation in patients after percutaneous coronary intervention: A meta-analysis of randomized controlled trials

Xinyu Yang  1   2 , Yanda Li  1   3 , Xiaomeng Ren  2   3 , Xingjiang Xiong  1 , Lijun Wu  2   3 , Jie Li  1 , Jie Wang  1 , Yonghong Gao  2 , Hongcai Shang  2 , Yanwei Xing  1
Affiliations
Meta-Analysis

Effects of exercise-based cardiac rehabilitation in patients after percutaneous coronary intervention: A meta-analysis of randomized controlled trials

Xinyu Yang et al. Sci Rep. .

Abstract

In this study, we assessed the effect of rehabilitation exercise after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). We performed a meta-analysis to determine the effects of exercise in patients after PCI. The Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, the Embase database, China National Knowledge Internet (CNKI), China Biology Medicine (CBM), and the Wanfang Database were searched for randomized controlled trials (RCTs). The key words used for the searches were PCI, exercise, walking, jogging, Tai Chi, and yoga. Six studies with 682 patients met our inclusion criteria; we chose the primary endpoint events of cardiac death, recurrence of myocardial infarction (MI), repeated PCI, coronary artery bypass grafting (CABG), and restenosis, and the secondary endpoint measures included recurrent angina, treadmill exercise (total exercise time, ST-segment decline, angina, and maximum exercise tolerance). The results showed that exercise was not clearly associated with reductions in cardiac death, recurrence of MI, repeated PCI, CABG, or restenosis. However, the exercise group exhibited greater improvements in recurrent angina, total exercise time, ST-segment decline, angina, and maximum exercise tolerance than did the control group. Future studies need to expand the sample size and improve the quality of reporting of RCTs.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1. Flow chart of the search strategy used to identify trials for inclusion in the meta-analysis.
RCT, randomized controlled trial.
Figure 2
Figure 2. Quality assessment of the included studies in this review: Risk of bias graph.
Figure 3
Figure 3. Quality assessment of included studies in this review: Risk of bias summary.
Figure 4
Figure 4. Forest plot of the meta-analysis of an exercise group and a control group with respect to the primary endpoint events.
(4.1) Cardiac death; (4.2) recurrence of MI; (4.3) repeated PCI; (4.4) CABG; (4.5) restenosis.
Figure 5
Figure 5. Forest plot of the meta-analysis of two studies with an exercise group and a control group with respect to the secondary endpoint measures.
(5.1) Recurrent angina and treadmill exercise: (5.2) total time exercise; (5.3) ST-segment decline; (5.4) angina; (5.5) maximum exercise tolerance.
See this image and copyright information in PMC

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