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. 1988 Jan;211(1):138-42.
doi: 10.1007/BF00338404.

Chromosome replication in Escherichia coli induced by oversupply of DnaA

Y C Xu  1 , H Bremer
Affiliations

Chromosome replication in Escherichia coli induced by oversupply of DnaA

Y C Xu et al. Mol Gen Genet. 1988 Jan.

Abstract

Overexpression of DnaA protein from a multicopy plasmid accompanied by a shift to 42 degrees C causes initiation of one extra round of replication in a dnaA+ strain grown in glycerol minimal medium. This extra round of replication does not lead to an extra cell division, such that cells contain twice the normal number of chromosomes.

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References

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