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Comparative Study
. 1988 Feb 11;16(3):1143-51.
doi: 10.1093/nar/16.3.1143.

Human transposon-like elements insert at a preferred target site: evidence for a retrovirally mediated process

N Deka  1 , C R Willard, E Wong, C W Schmid
Affiliations
Free PMC article
Comparative Study

Human transposon-like elements insert at a preferred target site: evidence for a retrovirally mediated process

N Deka et al. Nucleic Acids Res. .
Free PMC article

Abstract

Members of the human transposon-like family of repetitive sequences (called THE 1 repeats) like many other repetitive DNA sequences are flanked by short direct repeats. Comparison of the base sequences of twelve examples of these flanking direct repeats indicates that THE 1 repeats insert into a preferred genomic target site. In one case, we have identified the sequence of an empty site into which a THE 1 element inserted. The sequence of this empty site and sequences of truncated THE 1 LTRs are consistent with a retroviral mechanism for the insertion of THE 1 elements. Truncated transposon structures illustrate for the first time that intermediate structures of retrotransposition may also be integrated into the genome.

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References

    1. Nature. 1985 Jul 25-31;316(6026):359-61 - PubMed
    1. Nature. 1984 Jul 26-Aug 1;310(5975):332-3 - PubMed
    1. Nucleic Acids Res. 1985 Sep 11;13(17):6205-21 - PubMed
    1. Cell. 1986 Feb 28;44(4):555-63 - PubMed
    1. Nucleic Acids Res. 1986 May 12;14(9):3717-27 - PubMed

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